FieldDxBromidesDose, contraindications and adverse effects for Dogs.
What it is used for
Oral inorganic anticonvulsant. Management of idiopathic epilepsy / seizure control in dogs.
Dose by species
Doses are shown as published, not averaged across sources. Enter the animal’s body weight in the interactive drug guide to calculate the amount.
How it works
Chloride-ion competitor; hyperpolarizes neuronal membranes to raise seizure threshold.
Do not use in
Cats (high risk of severe, irreversible asthma-like pneumonitis).
Main adverse effects
A systematic review and meta-analysis of adverse effects of antiepileptic drugs in dogs showed strong evidence for potassium bromide safety profile as monotherapy and weak as an adjunctive therapy. Although no statistical significance was found, there was a trend for imepitoin, levetiracetam, and phenobarbital to have a safer profile than bromide.
Monitoring
■ Efficacy/toxicity. One review of the safety of potassium bromide in dogs states that clinical signs may be a better indication of the appropriateness of treatment than is monitoring serum bromide concentration alone.24 ■ Serum bromide concentrations.
Similar drugs
Source
Plumb (p. 137); Papich (pp. x, 22)
Plumb's Veterinary Drug Handbook, 10th Edition
Condensed and attributed, never reproduced whole. Open the full entry in the app.