FieldDxBupivacaineDose, contraindications and adverse effects for Cats, Cattle, Dogs, Goats, Horses and Sheep.
What it is used for
Long-acting local amide anesthetic. Local, regional, or epidural anesthesia and analgesia.
Dose by species
Doses are shown as published, not averaged across sources. Enter the animal’s body weight in the interactive drug guide to calculate the amount.
How it works
Blocks sodium channels in nerve fibers to inhibit action potential conduction.
Do not use in
Do not administer intravenously (high risk of fatal cardiotoxicity).
Main adverse effects
Local anesthetics are generally well tolerated when administered correctly. Adverse effects are related to high plasma concentrations, which may result from the dosage or bupivacaine concentration used, rapid absorption from the injection site, and unintentional intravascular or subarachnoid injection. Cardiovascular adverse effects include hypotension, bradycardia, AV block, and decreased cardiac output.
Monitoring
■ Adequacy of analgesia and anesthesia ■ Cardiovascular and respiratory function as well as state of consciousness after each injection
Source
Plumb (p. 144)
Plumb's Veterinary Drug Handbook, 10th Edition
Papich Handbook of Veterinary Drugs, 5th Edition (p. 99)
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