FieldDxDiminazene AceturateDose, contraindications and adverse effects for Cats and Dogs.
What it is used for
Aromatic diamidine derivative antiprotozoal. Treating Babesia gibsoni and Cytauxzoon felis.
Dose by species
Doses are shown as published, not averaged across sources. Enter the animal’s body weight in the interactive drug guide to calculate the amount.
How it works
Inhibits DNA synthesis in protozoa.
Do not use in
Camels appear highly susceptible to the toxic effects of diminazene, and product labels may state the drug is contraindicated in camelids. CNS toxic effects in dogs may be associated with cumulative dosages of diminazene, and repeated dosing must be carefully considered. One reference states, the dose cannot be repeated with this or another diaminidine-derivative within a 6-week period.
Main adverse effects
At usual dosages in domestic livestock, diminazene is reportedly relatively free of adverse effects. Adverse effects associated with therapeutic dosages of diminazene in dogs may include vomiting and diarrhea, pain and swelling at the injection site, and transient decreases in blood pressure. Very rarely (less than 0.1%), ataxia, seizures, or death have been reported.
Monitoring
■ For Babesia spp infections in dogs, monitoring should include surveillance for potential adverse effects of diminazene and signs of clinical efficacy, including baseline and periodic CBCs. Severe cases may have elevated BUN or liver enzymes and hypokalemia.
Conditions it is used for
Source
Plumb (pp. 379-380).
Plumb's Veterinary Drug Handbook, 10th Edition
Condensed and attributed, never reproduced whole. Open the full entry in the app.