EnrofloxacinDose, contraindications and adverse effects for Cats, Dogs, Horses and Poultry.

Fluoroquinolone antibiotic; bactericidal via inhibition of bacterial DNA gyrase and topoisomerase IV. Enrofloxacin, like other fluoroquinolones, is used to treat susceptible bacteria in a variety of species. Treatment has included infections of skin and soft tissue, urinary tract infections in dogs and cats, Chlamydophila felis infections in cats, and ulcerative colitis caused by E. coli in dogs. Enrofloxacin has been shown effective for treating Rickettsia infections in dogs. However, it is not e

Enrofloxacin is a fluoroquinolone antibacterial drug. Enrofloxacin acts via inhibition of DNA gyrase in bacteria to inhibit DNA and RNA synthesis. It is a bactericidal with a broad spectrum of activity. In most animal species, enrofloxacin is metabolized, at least partially, to ciprofloxacin.

Avoid use in young dogs because of risk of cartilage injury. Do not administer to young foals; injury to articular cartilage has been reported. Use cautiously in animals that may be prone to seizures, such as those with epilepsy. Do not administer to cats at doses greater than 5 mg/kg/day. Avoid use in older cats.

High concentrations may cause CNS toxicity. Animals with kidney disease may be more susceptible. It may cause occasional vomiting and, at high doses, may cause some nausea and diarrhea. All of the fluoroquinolones may cause arthropathy in young animals. Dogs are most sensitive at 4 weeks to 28 weeks of age. Large, rapidly growing dogs are the most susceptible. Cats are relatively resistant to cartilage injury, but foals are susceptible.

Susceptibility testing (from the Clinical and Laboratory Standards Institute [CLSI]): For dogs and cats, the breakpoint for susceptible organisms is ≤0.5 mcg/mL, and bacteria above 2 mcg/mL are clinically resistant.

A withdrawal interval is stated for this drug. It depends on the formulation, route and dose, so read the exact wording in the interactive drug guide before treating a food animal.