Hemoglobin Glutamer-200Dose, contraindications and adverse effects for Cats and Dogs.

A polymerized bovine hemoglobin-based oxygen carrier, used as a blood substitute when compatible blood is unavailable. Hemoglobin glutamer-200 (HG-200) is FDA-approved for the treatment of anemia in dogs, regardless of the cause of anemia (eg, hemolysis, blood loss, or ineffective erythropoiesis). HG-200 increases systemic oxygen content and improves clinical signs associated with anemia for at least 24 hours. It is likely more valuable in dogs with regenerative anemias than those with nonregenerative anemias

Hemoglobin glutamer-200 (HG-200) is a plasma volume expander with colloidal properties similar to dextran 70 and hetastarch. It is a bovine hemoglobin-based oxygen-carrying fluid that increases arterial oxygen content. The bovine hemoglobin in the product is polymerized into larger molecules to increase safety, efficacy, and intravascular persistence

Hemoglobin glutamer-200 (HG-200) is labeled as a single-dose treatment and should not be used in patients that have previously been treated with it. Administration of any foreign protein has the potential to cause immunologic reactions. Although low concentrations of IgG antibodies have been detected after administration of multiple doses, only rare, anecdotal reports of anaphylactic reactions have been reported.

Adverse effects that occur in more than 4% of dogs treated with HG- 200 include discoloration of mucous membranes, sclera (yellow, red, brown), urine (orange, red, brown), and skin (yellow); increased central venous pressure; ventricular arrhythmias (eg, AV block, tachycardia, premature ventricular contractions); ecchymoses/petechiae; bradycardia; vomiting; diarrhea; anorexia; tachypnea; dyspnea; pulmonary edema; harsh lung sounds/crackles; pleural effusion; fever

■ Hemoglobin ■ Clinical signs of adequate tissue oxygenation ■ Respiratory rate and character; thoracic auscultation ■ Physical examination to check for adverse effects ■ Attitude and demeanor ■ Central venous pressure