Interferon Alfa, HumanDose, contraindications and adverse effects for Cats and Dogs.

Human recombinant interferon used off label as an immunomodulator/antiviral in cats and dogs, notably for feline immunodeficiency virus infection. Interferon alfa has primarily been used in cats to treat a variety of virus- 682 Interferon Alfa, Human Recombinant induced diseases using either SC or oral/buccal administration. Despite rapid antibody development when injected parenterally and little, if any, absorption after oral administration, the drug does appear to have some efficacy for certain diseases, either via direct antiviral action

There are at least 25 subtypes of interferon alfa, each possessing similar but not identical biological activity. The pharmacologic effects of the interferons are widespread and complex. Suffice it to say that interferon alfa has antiviral, antiproliferative, and immunomodulating effects.

When interferon alfa is used parenterally, consider the risks versus benefits in patients with pre-existing autoimmune disease, severe cardiac disease, pulmonary disease, hard-to-control (brittle) diabetes, severe hepatic disease, herpes infections, hypersensitivity to the drug, or CNS disorders.

When interferon alfa is used orally in cats, adverse effects are apparently uncommon. Higher dosages given parenterally to cats may cause malaise, fever, allergic reactions, myelotoxicity, and myalgia. Injection site reactions (eg, discomfort, redness) are possible. Cats given human interferon-alfa parenterally may develop significant antibodies to it after 3 to 7 weeks of treatment with resultant loss of efficacy.

■ Baseline and periodic CBC with platelets and chemistry panel should be performed during treatment. ■ Consider measurement of serum triglycerides and thyroid panel, as abnormalities have been noted in humans ■ Baseline and periodic ophthalmic examinations to monitor for improvement or progression…