Lufenuron/Lufenuron CombinationDose, contraindications and adverse effects for Cats and Dogs.

Insect growth regulator; blocks chitin synthesis so flea eggs/larvae/pupae cannot develop a normal exoskeleton. Lufenuron is FDA-approved for oral use in dogs and cats for the control of flea populations; however, the oral products with lufenuron as a single agent are no longer marketed. The 6-month injectable (Program®) is indicated for flea control in cats. The lufenuron/ milbemycin oxime combination product (Sentinel®) is labeled for prevention and control of flea populations, prevention of heartwo

Lufenuron inhibits chitin synthesis, polymerization, and deposition in fleas, thereby preventing eggs from developing into adults. Af- ter biting a lufenuron-treated dog or cat, lufenuron is deposited in a female flea’s eggs. These eggs are prevented from hatching, thereby breaking the flea life cycle. Lufenuron does not kill adult fleas.

Lufenuron injection should only be given SC; do NOT inject IM. The feline-labeled injectable product should not be used in dogs as severe local reactions are possible. Oral lufenuron (Program® Flavor Tabs) is indicated for use in dogs and cats 4 weeks of age and older (oral suspension and Program® Cat Flavor Tabs are 6 weeks of age and older); the feline injectable lufenuron (ie, Program® 6 Month for Cats) is indicated for use in cats 6 weeks of age and older.

Adverse effects reported in dogs and cats after oral lufenuron include vomiting, diarrhea, anorexia, lethargy/depression, pruritus/urticaria, erythema, and dyspnea. Adverse effects following lufenuron injection in cats include pain on injection, injection site lumps/granulomas, vomiting, listlessness/ lethargy, and anorexia. After receiving the injectable product, a small lump or tissue reaction at the injection site has been noted in some cats.

■ Efficacy. It may take longer to see effect in colder geographic areas due to prolonged flea cycle in colder temperatures. ■ Adverse effects (eg, vomiting, diarrhea, anorexia, lethargy/depression, pruritus/urticaria, erythema, dyspnea