Thyrotropin-Releasing HormoneDose, contraindications and adverse effects for Cats, Dogs and Horses.

Hypothalamic hormone given IV as a diagnostic stimulation test; in horses with PPID, abnormal pituitary cells over-respond to TRH with an exaggerated ACTH rise. Thyrotropin-releasing hormone (TRH; protirelin) is most commonly used in veterinary medicine as a diagnostic agent (TRH stimulation test) for diagnosing pituitary pars intermedia dysfunction (PPID) in horses. While safe and fast, when measuring cortisol as the marker, false-positive results are relatively common. Combining this test with a dexamethasone suppression test can improve diagnostic te

Thyrotropin-releasing hormone directly stimulates thyrotropin secretion by the pituitary gland, thereby indirectly stimulating synthesis and secretion of thyroid hormones. In horses, thyrotropin-releasing hormone (TRH) can stimulate the equine pars intermedia and appears to directly stimulate equine melanotropes.

Contraindicated in patients that are hypersensitive to it. Use with caution in patients with seizure disorders as IV administration has rarely caused seizures in humans.

Hypersalivation, vomiting and restlessness were noted in healthy dogs. In horses, IV administration of TRH can cause transient muscle trembling, yawning, lip-smacking, flehmen, and coughing. In humans, TRH given by rapid IV injection or intranasally can cause nausea, a desire to urinate, flushing, dizziness, and a strange taste. Intranasal administration has rarely caused bronchospasm.