IvermectinDose, contraindications and adverse effects for Cats, Cattle, Dogs, Goats, Horses and Sheep.

Macrocyclic lactone antiparasitic. Endoparasites and ectoparasites, generalized demodicosis.

Binds glutamate-gated chloride channels (implied by class).

Do not administer to animals younger than 6 weeks of age. Animals with high numbers of microfilaremia may show adverse reactions to high doses. If dogs are sensitive to ivermectin (see earlier list of breeds), they may be sensitive to other drugs in this class (other avermectins). Ivermectin at approved clinical doses for treatment of endoparasites or heartworm prevention has been safe in pregnant animals.

Toxicity may occur at high doses and in breeds in which ivermectin crosses the blood–brain barrier. Sensitive breeds include collies, Australian shepherds, Old English sheepdogs, longhaired whippets, and Shetland sheepdogs. Toxicity is neurotoxic and signs include hypersalivation, depression, ataxia, difficulty with vision, coma, and death.

Monitor for microfilaremia prior to administration in small animals. For other parasitic infections, confirm successful treatment with fecal examinations or skin scrapings. Ivermectin 487

A withdrawal interval is stated for this drug. It depends on the formulation, route and dose, so read the exact wording in the interactive drug guide before treating a food animal.