Tolfenamic AcidDose, contraindications and adverse effects for Cats, Cattle, Dogs and Pigs.

Fenamic-acid-class NSAID; nonselective COX inhibitor used for pain, inflammation and fever. Tolfenamic acid is an anti-inflammatory, antipyretic, and analgesic agent approved in other countries for use in dogs, cats, cattle, and swine. Tolfenamic acid may be useful for the treatment of acute or chronic pain and/or inflammation in dogs and acute pain/inflammation in cats. In some countries, tolfenamic acid is approved for the treatment of pneumonia and acute mastitis in cattle and metri

NSAID.

Tolfenamic acid is contraindicated in animals hypersensitive to it or to other drugs in its class (eg, meclofenamic acid). Like other NSAIDs, it should not be used in animals with active GI bleeding or ulceration. Use with caution in patients with decreased renal or hepatic function. Avoid use in dehydrated, hypovolemic, or hypotensive animals. Use in animals under 6 weeks of age is not recommended.

Tolfenamic acid is relatively safe when given as recommended in dogs and cats. Vomiting and diarrhea have been reported after oral use. Experimental studies did not demonstrate significant renal or GI toxicity until doses were more than 10 times labeled. Potentially, long-term use could cause renal failure, especially in cats.

■ Clinical efficacy ■ Adverse effects Toltrazuril 1255