OclacitinibDose, contraindications and adverse effects for Cats and Dogs.

What it is used for

Immunosuppressive agent; labeled as Apoquel. Efficacy/safety of long-term use with systemic glucocorticoids or other immunosuppressives is not evaluated. Pruritus associated with allergic or atopic dermatitis in dogs.

Dose by species

Dose0.4–0.6 mg/kg PO every 12 hoursDogs

Dose0.5–0.7 mg/kg PO twice dailyDogs

Dose0.6 mg/kg PO every 12 hoursDogs

Dose0.5 mg/kg PO every 12 hoursDogs

Dose0.6–0.9 mg/kg PO twice dailyDogs

Doses are shown as published, not averaged across sources. Enter the animal’s body weight in the interactive drug guide to calculate the amount.

How it works

Immunosuppressive.

Do not use in

Relatively contraindicated for long-term use with cyclosporine, especially when infection is present.

Main adverse effects

Oclacitinib appears to be well tolerated in dogs, with an incidence of adverse effects similar to placebo. One study in allergic dogs showed that chronic use of oclacitinib for up to 630 days is generally safe. Most commonly, GI effects (eg, vomiting, diarrhea, anorexia) or lethargy have been noted; in most cases these effects are transient and resolve spontaneously.

Monitoring

■ Clinical efficacy ■ Development of infections (eg demodicosis, interdigital furunculosis, pneumonia, UTI) ■ Development of new (or exacerbations of existing) cutaneous or subcutaneous masses or other neoplasms ■ There are no data to support mandated bloodwork monitoring

Conditions it is used for

Canine Atopic Dermatitis

Source

Plumb (p. 529).

Plumb's Veterinary Drug Handbook, 10th Edition

Papich Handbook of Veterinary Drugs, 5th Edition (p. 665)

Condensed and attributed, never reproduced whole. Open the full entry in the app.