PrednisoloneDose, contraindications and adverse effects for Cats, Dogs and Horses.

Intermediate-acting corticosteroid; hepatically conjugated and excreted in urine. Labeled as Delta-cortef or PrednisTab. High oral bioavailability in horses. Inflammatory and immune-mediated conditions.

Glucocorticoid anti-inflammatory and immunomodulatory.

Systemic fungal infections; IM injection in animals with idiopathic thrombocytopenia; hypersensitivity.

There are many side effects from corticosteroids, which include polyphagia, polydipsia and polyuria, behavior changes, and hypothalamic–pituitary–adrenal (HPA) axis suppression. Adverse effects include GI ulceration, steroid hepatopathy, diabetes, hyperlipidemia, decreased thyroid hormone, decreased protein synthesis, delayed wound healing, increased risk of diabetes, and immunosuppression.

Monitor liver enzymes, blood glucose, and renal function during therapy. Monitor patients for signs of secondary infections. Perform an ACTH stimulation test to monitor adrenal function. Corticosteroids can increase liver enzymes, especially ALP, without inducing liver pathology.

A withdrawal interval is stated for this drug. It depends on the formulation, route and dose, so read the exact wording in the interactive drug guide before treating a food animal.