Triamcinolone DiacetateDose, contraindications and adverse effects for Horses.

Synthetic glucocorticoid corticosteroid, used for its anti-inflammatory and immunosuppressive effects. Triamcinolone acetonide, like other corticosteroids, is used to treat inflammatory and immune-mediated diseases in animals. It is used for similar purposes as prednisolone, except with higher potency. It is an acceptable substitute for prednisolone in cats. Triamcinolone acetonide suspension is also used for intralesional and intraarticular injections to produce local antiinflammatory effects

Triamcinolone acetonide is a glucocorticoid antiinflammatory drug. Anti- inflammatory effects are complex, but they are primarily via inhibition of inflammatory cells and suppression of expression of inflammatory mediators.

Do not administer injectable suspension IV. The injectable product is intended for IM, intraarticular, or intralesional injection. Use cautiously in patients prone to ulcers or infection and in animals in which wound healing is necessary. Do not use the ocular form in animals with corneal ulcers. Use cautiously in animals with diabetes or renal failure and in pregnant animals.

Side effects from corticosteroids are many and include polyphagia, polydipsia and polyuria, and hypothalamic–pituitary–adrenal axis suppression. Injections of triamcinolone acetonide can have long-lasting effects. In people, injections can produce adrenal suppression for 30 days. Other adverse effects include GI ulceration, hepatopathy, diabetes, hyperlipidemia, decreased thyroid hormone, decreased protein synthesis, impaired wound healing, and immunosuppression.

Monitor liver enzymes, blood glucose, and renal function during therapy. Monitor patients for signs of secondary infections. Perform an adrenocorticotropic hormone (ACTH) stimulation test to monitor adrenal function.