Amoxicillin/ClavulanateDose, contraindications and adverse effects for Cats, Dogs and Poultry.

What it is used for

Potentiated penicillin class antibiotic. Pyoderma, skin infections, UTIs, and susceptible beta-lactamase-producing infections.

Dose by species

Dose13.75 mg/kg PO twice dailyDogs

Dose12.5–25 mg/kg PODogs

Dose12.5–25 mg/kg PO twice dailyDogs

Dose12.5–25 mg/kg POCats

Dose50–100 mg/kg POBirds

Dose10–20 mg/kg POFerrets

Doses are shown as published, not averaged across sources. Enter the animal’s body weight in the interactive drug guide to calculate the amount.

How it works

Clavulanate potassium inactivates bacterial beta-lactamases, protecting amoxicillin from degradation.

Do not use in

Hypersensitivity to penicillins/beta-lactams.

Main adverse effects

Adverse effects with the penicillins are usually not serious and have a relatively low frequency of occurrence. Hypersensitivity reactions unrelated to dose can occur with these agents and can manifest as rashes (including severe cutaneous reactions), fever, eosinophilia, neutropenia, agranulocytosis, thrombocytopenia, leukopenia, anemia, lymphadenopathy, or anaphylaxis. When penicillins are given orally, they may cause GI effects (eg, anorexia, vomiting, diarrhea).

Monitoring

■ Efficacy: resolution of clinical signs ■ Culture and susceptibility as indicated for clinical condition being treated. ■ Urine culture may be considered after 5 to 7 days when treating bacterial cystitis for longer periods of time.

Conditions it is used for

Melioidosis Watery Mouth of Lambs

Source

Plumb (p. 70); Papich (pp. x, 17)

Plumb's Veterinary Drug Handbook, 10th Edition

Papich Handbook of Veterinary Drugs, 5th Edition (p. 47)

Condensed and attributed, never reproduced whole. Open the full entry in the app.