Penicillin GDose, contraindications and adverse effects for Cattle, Horses, Pigs and Sheep.

Beta-lactam antibiotic available in various salt formulations. Susceptible bacterial infections.

Time-dependent, bactericidal beta-lactam antibiotic.

Use cautiously in animals allergic to penicillin-like drugs. Avoid injection volumes greater than 30 mL per site. Administration of the longacting benzathine form of penicillin G increases the risk of residues in food-producing animals.

Penicillin G has a high safety margin and is usually well tolerated. Allergic reactions are possible. Diarrhea is common with oral doses, but oral forms are rarely used. Pain and tissue reactions may occur with IM or SQ injections. Formulations of procaine penicillin G contain varying amounts of free procaine (depending on the formulation). Free procaine in the formulation may elicit a central nervous system (CNS) reaction after injection in some horses.

Susceptibility testing: Clinical and Laboratory Standards Institute (CLSI) breakpoint for susceptible equine pathogens (Streptococcus equi and Staphylococcus spp.) is ≤0.5 mcg/mL. The breakpoint for bovine isolates causing bovine respiratory disease is ≤0.25 mcg/mL.

A withdrawal interval is stated for this drug. It depends on the formulation, route and dose, so read the exact wording in the interactive drug guide before treating a food animal.