Ceftiofur HClDose, contraindications and adverse effects for Cattle and Pigs.

Third-generation cephalosporin antibiotic developed specifically for veterinary use in food animals; a beta-lactam that inhibits bacterial cell wall synthesis. In cattle, ceftiofur HCl is FDA-approved for the treatment of the following bacterial diseases: Bovine respiratory diseases (eg, BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni; acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus; and…

Ceftiofur is a third-generation, time-dependent, bactericidal cephalosporin antibiotic that is active against a variety of gram-positive and gram-negative bacteria and that, like other cephalosporins, inhibits bacteria cell wall synthesis. Ceftiofur is rapidly cleaved into furoic acid and desfuroylceftiofur (active).

Cephalosporins are contraindicated in patients with a history of hypersensitivity to them. Hypersensitivity reactions unrelated to dosage can occur with cephalosporin antibiotics and manifest as rashes, fever, eosinophilia, lymphadenopathy, or anaphylaxis. Use of cephalosporins in patients documented to be hypersensitive to penicillin-class antibiotics is controversial.

Adverse effects with the cephalosporins are usually not serious and Ceftiofur HCl 225 have a relatively low frequency of occurrence, but cephalosporins can cause allergic reactions in sensitized individuals. Topical exposures to such antimicrobials, including ceftiofur, may elicit mild to severe allergic reactions in some individuals. Repeated or prolonged exposure may lead to sensitization.

Because minimal toxicity is associated with use of cephalosporins, monitoring for efficacy is usually all that is required. Patients with diminished renal function may require intensified renal monitoring. Therapeutic drug monitoring is not typically done.

A withdrawal interval is stated for this drug. It depends on the formulation, route and dose, so read the exact wording in the interactive drug guide before treating a food animal.